Published by the Australian Signals Directorate, their version of the NSA, the first four mitigations are mandatory for all Australian government computers. For my (non-existent) readers application whitelisting may be a bit beyond your scope but the other 3 are definitely something that you should be doing:
Secunia is an excellent program for handling item (2) and windows update covers (3) if you you use Windows. Over the next couple days I will put up some instructions on how to deal with all these, but for now something to think about. Even though you probably aren't actually being targeted specifically it's just a good idea to take some basic precautions especially in the era of things like Ransomware.